ANTINOCICEPTIVE EFFECT OF D-ASPARTIC ACID IN MICE

ONAT F., TOKER F., ASLAN N., OKTAY S., BERKMAN K.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.51, sa.4, ss.715-719, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0091-3057(95)00016-p
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.715-719
  • Anahtar Kelimeler: ASPARTIC ACID, ANALGESIA, MORPHINE, NALOXONE, RAT SPINAL-CORD, AMINO-ACIDS, DORSAL HORN, MORPHINE-DEPENDENCE, KETAMINE ANALGESIA, NMDA RECEPTORS, NALOXONE, GLUTAMATE, NEURONS, NEUROTRANSMISSION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

The effects of D- and L-aspartic acids on the nociceptive tail flick reflex in mice were investigated. D-Aspartic acid (115-230 mg/kg, IF) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of D-aspartic acid (115 mg/kg). Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of D-aspartic acid. Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase. L-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.