ANTINOCICEPTIVE EFFECT OF D-ASPARTIC ACID IN MICE

ONAT F., TOKER F., ASLAN N., OKTAY S., BERKMAN K.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, vol.51, no.4, pp.715-719, 1995 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 1995
  • Doi Number: 10.1016/0091-3057(95)00016-p
  • Journal Name: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.715-719
  • Keywords: ASPARTIC ACID, ANALGESIA, MORPHINE, NALOXONE, RAT SPINAL-CORD, AMINO-ACIDS, DORSAL HORN, MORPHINE-DEPENDENCE, KETAMINE ANALGESIA, NMDA RECEPTORS, NALOXONE, GLUTAMATE, NEURONS, NEUROTRANSMISSION
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

The effects of D- and L-aspartic acids on the nociceptive tail flick reflex in mice were investigated. D-Aspartic acid (115-230 mg/kg, IF) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of D-aspartic acid (115 mg/kg). Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of D-aspartic acid. Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase. L-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.