Short- and long-term effects of individualized enteral protein supplementation in preterm newborns

ERGENEKON N. E., Soysal S., Hirfanoglu I., Bas V., GÜCÜYENER K., Turan O., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.55, no.4, pp.365-370, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2013
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.365-370
  • Keywords: preterm newborn, enteral protein, growth, neurodevelopmental outcome, IMPROVING HEAD GROWTH, HUMAN-MILK, INFANTS, OUTCOMES, TRIAL, TRANSTHYRETIN, FORTIFICATION, IMPACT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


The aim of this retrospective study was to assess the need for additional enteral protein supplementation in preterm newborns with gestational age (GA) <= 32 weeks after full enteral feeds with either fortified breast milk (FBM) or preterm formula (PF) were reached, and to determine the effects of additional protein on physical and neurological development. After the standard early total parenteral nutrition (TPN) and reaching full enteral nutrition with 150-160 ml/kg/day, preterms were assessed for the requirement of additional protein based on serum blood urea nitrogen (BUN)/prealbumin levels. Additional enteral protein was given for BUN <5 mg/dl and/or prealbumin <= 8 mg/dl with weekly assessments as per Neonatal Intensive Care Unit (NICU) protocol. Growth in the NICU and neurodevelopmental outcome at 18 months' corrected age (CA) were determined.