Does Ozone Administration Have a Protective Effect Against Cisplatin- induced Histological Changes in Rat Testis?

Aydogdu I., Ekin R. G., Yildiz P., Mirapoglu S. L., Cay A., Aydogdu Y. E., ...More

JOURNAL OF UROLOGICAL SURGERY, vol.6, no.1, pp.32-37, 2019 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.4274/jus.galenos.2018.2225
  • Journal Name: JOURNAL OF UROLOGICAL SURGERY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.32-37
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Objective: We investigated the protective and therapeutic effects of ozone therapy (OT) on cisplatin (CP)-induced testicular damage. Materials and Methods: Thirty healthy adult male Wistar rats were divided into five groups consisting of 6 animals each: 1) control, 2) CP, 3) OT, 4) OT + CP and 5) CP + OT groups. Histopathological findings, Johnsen scores, thiobarbituric acid-reactive substances (TBARS), glutathione (GSH), superoxide dismutase (SOD), catalase, and GSH peroxidase (GPx) levels were evaluated. Results: CP caused a significant decrease in testicular weight and Johnsen score compared to the control group. In addition, TBARS level was significantly higher, whereas GSH, SOD, catalase and GPx levels were significantly lower in the CP group when compared to the control group. Pre- and post-CP OT significantly increased GSH, SOD, catalase and GPx levels and decreased TBARS level. Also, testicular weight and Johnsen score were increased with OT. Conclusion: The present study showed that OT is protective against CP-induced testicular damage. OT may be beneficial to patients who underwent CP chemotherapy.