An Unusual Presentation of a Chronic Lymphocytic Leukemia Patient with 17p Deletion After Reduced-Intensity Transplantation: Richter Syndrome and Concomitant Graft-Versus-Host Disease-Case Report


Salihoglu A., Ozbalak M., Keskin D., Tecimer T., Soysal T., Ferhanoglu B.

TRANSPLANTATION PROCEEDINGS, vol.45, no.7, pp.2845-2848, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 7
  • Publication Date: 2013
  • Doi Number: 10.1016/j.transproceed.2012.12.001
  • Title of Journal : TRANSPLANTATION PROCEEDINGS
  • Page Numbers: pp.2845-2848

Abstract

Chronic lymphocytic leukemia (CLL) patients with 17p deletion comprise a challenging subgroup associated with poor overall survival. These patients should be treated with alternative strategies. Reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) can achieve long-term remission in this ultra-high-risk CLL group. Herein, we described a CLL patient with 17p deletion who developed Richter syndrome with extranodal involvement of the liver soon after RIC allo-SCT despite apparent acute graft-versus-host disease.