A developmental study of glutamatergic neuron populations in the ventrobasal and the lateral geniculate nucleus of the thalamus: Comparing Genetic Absence Rats from Strasbourg (GAERS) and normal control wistar rats


Kirazhi O., Caydar S., Yildizel S., Onat F. , Kaptanoglu E.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol.56, pp.35-41, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijdevneu.2016.12.001
  • Title of Journal : INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Page Numbers: pp.35-41

Abstract

An imbalance of GABAergic inhibition and glutamatergic excitation is suspected to be the cause of absence epileptic seizures. Absence seizures are known to be generated in thalamocortical circuitry. In the present study we used light microscopy immunohistochemistry to quantify the density of glutamate+ve neurons at two developmental stages (P10 and P60) in two thalamic nuclei, the ventrobasal (VB) and lateral geniculate nucleus (LGN) in Wistar rats and compared the results with similar data obtained from genetic absence epilepsy rats from Strasbourg (GAERS).