Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy
GYNECOLOGICAL ENDOCRINOLOGY, cilt.35, sa.7, ss.635-637, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 7
- Basım Tarihi: 2019
- Doi Numarası: 10.1080/09513590.2018.1563889
- Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.635-637
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Intrahepatic cholestasis of pregnancy is a diagnosis of exclusion and presents with unexplained pruritus, abnormal liver function tests, and increased serum bile acid levels, particularly in the third trimester of pregnancy. Serum YKL-40 levels are increased in liver diseases and our aim was to investigate YKL-40 levels in pregnant women with ICP. 40 women with intrahepatic cholestasis of pregnancy and 40 healthy pregnant women were included in this cross-sectional study. Serum YKL-40 levels were measured in both groups and correlation analysis were performed between the YKL-40 and other liver function tests. Serum YKL-40 concentrations were higher in the intrahepatic cholestasis of pregnancy group than in the control group (103.4653.03 vs. 57.6030.30ng/ml, p=.002). The cutoff YKL-40 serum concentration was 84.80ng/ml for the diagnosis of intrahepatic cholestasis of pregnancy. There was no correlation between fasting bile acids and YKL-40 levels. However, there was a significant positive correlation between the YKL-40 levels and aspartate aminotransferase (r=0.22, p=.04) and alanine aminotransferase (r=0.24, p=.02). Raised YKL-40 levels might support the evidence on inflammatory processes in intrahepatic cholestasis of pregnancy.