Comparison of clinical outcomes associated with RSV and influenza infections in adults: a multicenter study from Türkiye (for AP-TR)
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.172, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 172
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.ijid.2026.109071
- Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest)
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet
Özet
Objectives: Respiratory syncytial virus (RSV) is an increasingly recognized cause of serious respiratory illness in adults, yet data from middle-income countries remain scarce. This study aimed to compare clinical outcomes of RSV and influenza virus infections in hospitalized and outpatient adults in T & uuml;rkiye. Methods: This retrospective multicenter study included 3299 adult patients ( >= 18 years) with polymerase chain reaction-confirmed RSV ( n = 628) or influenza ( n = 2671) from 21 centers across T & uuml;rkiye between January 2022 and March 2024. The primary outcome was viral infection-related hospitalization. The secondary composite outcome was intensive care unit (ICU) admission and/or 30-day mortality among hospitalized patients. Propensity score-based overlap weighting was used to adjust for baseline differences including age, risk group, clinical severity, co-infection status, and study center. Results: After overlap weighting, RSV infection was not significantly associated with increased hospitalization risk compared to influenza (odds ratio [OR]: 0.96, 95% confidence interval [CI]: 0.77-1.20, P = 0.705). Similarly, no significant difference was observed in the composite outcome of ICU admission or 30-day mortality (OR: 1.40, 95% CI: 0.95-2.05, P = 0.088). Age >= 60 years, high-risk comorbidities, and severe acute respiratory infection presentation were the primary independent predictors of both hospitalization and worse outcomes. Bacterial or fungal co-infections and secondary infections were observed in 12.9% and 7.3% of hospitalized patients, respectively, with no significant difference between RSV and influenza groups. Conclusion: After adjustment for baseline characteristics, RSV and influenza were associated with comparable risks of hospitalization and severe clinical outcomes in adults. Host-related factors, particularly older age and underlying comorbidities, were the dominant determinants of adverse outcomes. These findings from a largely unvaccinated, middle-income country cohort highlight the need to expand RSV and influenza vaccination programs targeting high-risk adult populations. (c) 2026 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)