RESTORATION OF BLOOD-PRESSURE BY CHOLINE TREATMENT IN RATS MADE HYPOTENSIVE BY HEMORRHAGE


ULUS İ. H. , ARSLAN B., SAVCI V., KIRAN B.

BRITISH JOURNAL OF PHARMACOLOGY, cilt.116, ss.1911-1917, 1995 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 116 Konu: 2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1111/j.1476-5381.1995.tb16682.x
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.1911-1917

Özet

1 Intracerebroventricular (i.c.v.) injection of choline (25 - 150 mu g) increased blood pressure in rats made acutely hypotensive by haemorrhage. Intraperitoneal administration of choline (60 mg kg(-1)) also increased blood pressure, but to a lesser extent. Following i.c.v. injection of 25 mu g or 50 mu g of choline, heart rate did not change, while 100 mu g or 150 pg i.c.v. choline produced a slight and short lasting bradycardia. Choline (150 mu g) failed to alter the circulating residual volume of blood in haemorrhaged rats.