RESTORATION OF BLOOD-PRESSURE BY CHOLINE TREATMENT IN RATS MADE HYPOTENSIVE BY HEMORRHAGE


ULUS İ. H. , ARSLAN B., SAVCI V., KIRAN B.

BRITISH JOURNAL OF PHARMACOLOGY, vol.116, no.2, pp.1911-1917, 1995 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 2
  • Publication Date: 1995
  • Doi Number: 10.1111/j.1476-5381.1995.tb16682.x
  • Title of Journal : BRITISH JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.1911-1917

Abstract

1 Intracerebroventricular (i.c.v.) injection of choline (25 - 150 mu g) increased blood pressure in rats made acutely hypotensive by haemorrhage. Intraperitoneal administration of choline (60 mg kg(-1)) also increased blood pressure, but to a lesser extent. Following i.c.v. injection of 25 mu g or 50 mu g of choline, heart rate did not change, while 100 mu g or 150 pg i.c.v. choline produced a slight and short lasting bradycardia. Choline (150 mu g) failed to alter the circulating residual volume of blood in haemorrhaged rats.