Th17 cells and tissue remodeling in atopic and contact dermatitis


Simon D., Aeberhard C., Erdemoglu Y. , Simon H. -.

ALLERGY, vol.69, no.1, pp.125-131, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.1111/all.12351
  • Title of Journal : ALLERGY
  • Page Numbers: pp.125-131

Abstract

BackgroundEczematous skin lesions of atopic dermatitis (AD) as well as allergic and irritant contact dermatitis (ACD, ICD) are characterized by the same typical clinical signs, although due to different causes. In both AD and ACD, the presence of T helper 17 cells which play an important role in host defense, has been reported. Furthermore, IL-17 is involved in tissue repair and remodeling. This study aimed to investigate IL-17 expression in acute eczematous skin lesions and correlate it with markers of remodeling in AD, ACD, and ICD.