GORM Gynecology Obstetrics & Reproductive Medicine, cilt.17, ss.20-23, 2011 (Diğer Kurumların Hakemli Dergileri)
OBJECTIVE: To evaluate the efficacy of single-dose fosfomycin tromethamine (FT) treatment in pregnant women with uncomplicated lower urinary tract infection (UTI).
STUDY DESIGN: In this study, 421 pregnant women with established, symptomatic, uncomplicated
lower UTI were randomly allocated to receive either a single dose of FT (Monurol®, Zambon Group
S.p.A, Milan-ITALY) (n=217) or a 7-day course of nitrofurantoin (n=204). The treatment was found to be
effective if urine culture was negative 15 days after therapy.
RESULTS: Microbiological cure was achieved in 205 (94.5%) patients treated with FT and 164 (80.4%)
patients treated with nitrofurantoin (p<0.05). Pathogen microorganisms were predominantly E.coli (199
in FT and 183 in NF group) followed by Klebsiella (18 in FT and 21 in NF group).
CONCLUSION: The treatment of acut lower UTI in pregnant women is essential. FT is an effective, safe,
single dose treatment choice in the management of uncomplicated lower UTI in pregnant women.