The levels of circulating markers of atherosclerosis and inflammation in subjects with different degrees of body mass index: Soluble CD40 ligand and high-sensitivity C-reactive protein


Guldiken S., Demir M., Arikan E., Turgut B., Azcan S., Gerenli M., ...More

THROMBOSIS RESEARCH, vol.119, no.1, pp.79-84, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 119 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.thromres.2005.12.019
  • Journal Name: THROMBOSIS RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.79-84
  • Keywords: obesity, atherosclerosis, inflammation, C-reactive protein, sCD40L, INSULIN-RESISTANCE, CARDIOVASCULAR RISK, OBESITY, INTERLEUKIN-6, ASSOCIATIONS, ACTIVATION, EXPRESSION, HEALTHY, DISEASE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: It is welt demonstrated that obesity is an independent risk factor for cardiovascular diseases. Recent studies have shown that obesity, insulin resistance and atherosclerosis are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown that CD40-soluble CD40 ligand (sCD40L) interactions might constitute an important mediator for vascular inflammation. The aim of the present study was to assess sCD40L in relation to hs-CRP and cardiovascular risk factors in relation to body mass index (BMI).