Longitudinal analysis of treatment-induced genomic alterations in gliomas


Erson-Omay E. Z. , Henegariu O., Omay S. B. , Harmanci A. S. , Youngblood M. W. , Mishra-Gorur K., ...Daha Fazla

GENOME MEDICINE, cilt.9, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.