Longitudinal analysis of treatment-induced genomic alterations in gliomas

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Erson-Omay E. Z., Henegariu O., Omay S. B., Harmanci A. S., Youngblood M. W., Mishra-Gorur K., ...Daha Fazla

GENOME MEDICINE, cilt.9, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s13073-017-0401-9
  • Dergi Adı: GENOME MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.