Longitudinal analysis of treatment-induced genomic alterations in gliomas

Erson-Omay, E.; Henegariu, Octavian; Omay, S.; Harmanci, Akdes; Youngblood, Mark; Mishra-Gorur, Ketu; Li, Jie; ÖZDUMAN, KORAY; Carrion-Grant, Geneive; Clark, Victoria; Caglar, CANER; Bakircioglu, Mehmet; Pamir, M.; Tabar, Viviane; Vortmeyer, Alexander; Bilguvar, KAYA; Yasuno, Katsuhito; DeAngelis, Lisa; Baehring, Joachim; Moliterno, Jennifer; Gunel, Murat

doi:10.1186/s13073-017-0401-9

Longitudinal analysis of treatment-induced genomic alterations in gliomas

Erson-Omay E. Z., Henegariu O., Omay S. B., Harmanci A. S., Youngblood M. W., Mishra-Gorur K., ...Daha Fazla

GENOME MEDICINE, cilt.9, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 9
Basım Tarihi: 2017
Doi Numarası: 10.1186/s13073-017-0401-9
Dergi Adı: GENOME MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.