Longitudinal analysis of treatment-induced genomic alterations in gliomas

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Erson-Omay E. Z., Henegariu O., Omay S. B., Harmanci A. S., Youngblood M. W., Mishra-Gorur K., ...More

GENOME MEDICINE, vol.9, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2017
  • Doi Number: 10.1186/s13073-017-0401-9
  • Journal Name: GENOME MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to understand the molecular basis of this variability.