Corneal Biomechanical Properties in Aspirin Users.

ÇELEBİ A. R. C., Kilavuzoglu A. E., Altiparmak U. E., Cosar C. B.

Ophthalmic research, vol.55, no.4, pp.199-204, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1159/000443892
  • Journal Name: Ophthalmic research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.199-204
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


Purpose: To analyze corneal biomechanical properties in aspirin users using an ocular response analyzer. Methods: This study included 80 eyes of 40 aspirin users and 80 eyes of 40 individuals who did not use aspirin. Corneal hysteresis (CH), the corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg), and corneal compensated intraocular pressure (IOPcc) were measured in all participants. The independent samples t test was used to compare measurements in the aspirin users and nonusers in the total study population, and in the diabetic patient subgroup. Pearson's correlation analysis was used to examine the relationship between the measured variables in the aspirin users and nonusers. Results: Aspirin users (59.08 +/- 11.83 years) were older than nonusers (39.82 +/- 12.97 years; p < 0.001). The mean CH was significantly lower in the aspirin user group than in the nonuser group (p = 0.013). Mean IOPg and mean IOPcc were also significantly higher in the aspirin user group (p = 0.027 and p = 0.002, respectively). The mean CRF was lower in the aspirin user group, but not significantly (p = 0.70). There was a positive correlation between CH and CRF (r = 0.767, p < 0.001), and between CRF and IOPg (r = 0.680, p < 0.001), and a negative correlation between CH and 10Pcc (r = -0.415, p < 0.001). Conclusions: Aspirin should be taken into account when interpreting the results of corneal biomechanical measurements. (C) 2016 S. Karger AG, Basel