Objective: Catheter-related infections are serious problems in current surgical practice. New coating materials have been produced to eliminate the infections. We aimed to evaluate the antiinfectious effects of Proshield (R) "organosilane quaternary amine" (Nano Technology Marketing Company -Istanbul) coated catheters. Material and Methods: Twenty one Sprague-Dawley rats were equally divided into three groups. In all rats, one Proshield coated and one non-coated catheter were placed in the same space. In group A, the catheters were put in the abdomen, in group B into the bladder and in group C in the subcutaneous space. In all rats, cultured 106 cfu/ml bacteria were given to same place with the catheters (S.aureus into abdomen and subcutaneous tissue, E. coli into bladder). Fifteen days after surgery, the catheters were removed, microbiologic and histopathologic analyses were made. Results: In both proshield coated and non-coated catheters, similar histopathologic findings were obtained. In all groups, proshield coated catheters had less colonization compared to non-coated catheters, but the difference was not significant (p>0.05). Conclusion: Antiseptic or antibiotic-soaked catheters are products to avoid infections proven by many studies and have decreased bacterial colonization rates compared to the standard non-coated catheters. Likewise, Proshield coated catheters may also be beneficial against bacterial colonization, but new technologies are required to produce more effective catheters.