Prevalence of antimicrobial resistance in Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis and Streptococcus pyogenes: results of a multicentre study in Turkey

Gur D., Ozalp M., Sumerkan B., KAYGUSUZ A., Toreci K., Koksal I., ...More

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol.19, no.3, pp.207-211, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1016/s0924-8579(02)00003-1
  • Journal Name: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.207-211
  • Keywords: antimicrobial resistance, Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis, Streptococcus pyogenes, ANTIBIOTIC-RESISTANCE, UNITED-STATES, SUSCEPTIBILITIES, SURVEILLANCE, AMPICILLIN, COUNTRIES
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

The in vitro activities of several antimicrobial agents against clinical isolates of Streptococcus pneumoniae (283), Haemophilus influenzae (272), Moraxella catarrhalis (179) and Streptococcus pyogenes (256) were determined in a multicentre study with the participation of five hospitals from four cities in Turkey. Penicillin resistance in S. pneumoniae was evaluated using the E-test and the remaining agents by disk diffusion. For S. pneumoniae overall 25.8% of the isolates were intermediately and 3.9% were highly resistant to penicillin and resistance to chloramphenicol, azithromycin and trimethoprim/sulphamethoxazole (TMP/SMX) was 3.8, 2.1 and 55.4%,, respectively. Seven percent of H. influenzae produced P-lactamase and all were susceptible to cefotaxime and azithromycin; the highest rate of resistance, 23.5%, was for TMP/SMX. Eighty-one percent of M. catarrhalis isolates produced beta-lactamase, 18.4% were resistant to TMP/SMX and all were susceptible to sulbactam/ampicillin combination. Resistance to chloramphenicol and azithromycin of S. pyogenes was 2.2 and 1.9%, respectively. (C) 2002 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.