Tumor necrosis factor-alpha inhibitors for the treatment of psoriasis patients with liver cirrhosis: A report of four cases with a literature review

ERGUN S. A. T., Seckin-Gencosmanoglu D., Salman A., Qzgen Z., Ocak E. S., Avsar E., ...Daha Fazla

INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY, cilt.83, sa.1, ss.55-59, 2017 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 83 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4103/0378-6323.186498
  • Dergi Adı: INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.55-59
  • Anahtar Kelimeler: Adalimumab, cirrhosis, etanercept, infliximab, psoriasis, TNF-alpha inhibitors, CHRONIC HEPATITIS-C, PRIMARY BILIARY-CIRRHOSIS, RHEUMATOID-ARTHRITIS, ETANERCEPT, THERAPY, ANTAGONISTS, DISEASE, GUIDELINES, INFECTION, FIBROSIS
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Patients with psoriasis are at an increased risk of developing liver disease due to various factors. The existing data regarding the treatment of psoriasis patients with associated liver cirrhosis is limited. We report four patients of psoriasis with liver cirrhosis who were treated with TNF-alpha inhibitors for a mean duration of 35.4 months. Two patients were treated with etanercept, one with adalimumab and one was treated with both infliximab and etanercept. Three patients tolerated the treatment well without any deterioration of liver disease whereas one died of progressive liver disease. Although large-scale, controlled studies are needed, this case series provides insights regarding the long-term safety of TNF-alpha inhibitors in patients with psoriasis and liver cirrhosis.