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Hirakawa H., Pierce R. A., Bingol-Karakoc G., KARAASLAN İ. Ç., Weng M., Shi G., ...More
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.176, no.8, pp.778-785, 2007 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
176
Issue:
8
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Publication Date:
2007
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Doi Number:
10.1164/rccm.200704-519oc
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Journal Name:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.778-785
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Keywords:
cathepsin, bronchopulmonary dysplasia, hyperoxia, myofibroblast, LOW-BIRTH-WEIGHT, CYSTEINE PROTEASES, BRONCHOPULMONARY DYSPLASIA, PULMONARY-FIBROSIS, PRETERM LAMBS, BABOON MODEL, RAT LUNG, APOPTOSIS, EXPRESSION, ATHEROSCLEROSIS
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Acibadem Mehmet Ali Aydinlar University Affiliated:
No
Abstract
Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.