Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury


Hirakawa H., Pierce R. A. , Bingol-Karakoc G. , KARAASLAN İ. Ç. , Weng M., Shi G., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.176, no.8, pp.778-785, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 176 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1164/rccm.200704-519oc
  • Title of Journal : AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Page Numbers: pp.778-785

Abstract

Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.