AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.176, no.8, pp.778-785, 2007 (Journal Indexed in SCI)
Article / Article
Title of Journal :
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
cathepsin, bronchopulmonary dysplasia, hyperoxia, myofibroblast, LOW-BIRTH-WEIGHT, CYSTEINE PROTEASES, BRONCHOPULMONARY DYSPLASIA, PULMONARY-FIBROSIS, PRETERM LAMBS, BABOON MODEL, RAT LUNG, APOPTOSIS, EXPRESSION, ATHEROSCLEROSIS
Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.