Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury

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Hirakawa H., Pierce R. A., Bingol-Karakoc G., KARAASLAN İ. Ç., Weng M., Shi G., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.176, no.8, pp.778-785, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 176 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1164/rccm.200704-519oc
  • Journal Name: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.778-785
  • Keywords: cathepsin, bronchopulmonary dysplasia, hyperoxia, myofibroblast, LOW-BIRTH-WEIGHT, CYSTEINE PROTEASES, BRONCHOPULMONARY DYSPLASIA, PULMONARY-FIBROSIS, PRETERM LAMBS, BABOON MODEL, RAT LUNG, APOPTOSIS, EXPRESSION, ATHEROSCLEROSIS
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Rationale Bronchopulmonary dysplasia (BPD) is a chronic lung disease that adversely affects long-term pulmonary function as well as neurodevelopmental outcomes of preterm infants. Elastolytic proteases have been implicated in the pathogenesis of BPD. Cathepsin S (cat S) is a cysteine protease with potent elastolytic activity. Increased levels and activity of cat S have been detected in a baboon model of BPD.