Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation

Hatipoglu I., Ercan D., Acilan C., Basalp A., Durali D., Baykal A. T.

IMMUNOBIOLOGY, cilt.219, sa.12, ss.944-949, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 219 Sayı: 12
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.imbio.2014.07.020
  • Dergi Adı: IMMUNOBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.944-949
  • Anahtar Kelimeler: Dendritic cell, HBeAg, Hepatitis B virus, LC-MS/MS, Proteomics, NF-KAPPA-B, SUPPRESSOR-CELLS, STATISTICAL-MODEL, CORE PROTEINS, INFECTION, S100A9, DIFFERENTIATION, ACCUMULATION, ACTIVATION, EXPRESSION
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses during chronic infection. Hence, studying the role of HBV in immune suppression is very important for the development of alternative therapeutic strategies for HBV infections.