Hepatitis B virus e antigen (HBeAg) may have a negative effect on dendritic cell generation

Hatipoglu I., Ercan D., Acilan C., Basalp A., Durali D., Baykal A. T.

IMMUNOBIOLOGY, vol.219, no.12, pp.944-949, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 219 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1016/j.imbio.2014.07.020
  • Journal Name: IMMUNOBIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.944-949
  • Keywords: Dendritic cell, HBeAg, Hepatitis B virus, LC-MS/MS, Proteomics, NF-KAPPA-B, SUPPRESSOR-CELLS, STATISTICAL-MODEL, CORE PROTEINS, INFECTION, S100A9, DIFFERENTIATION, ACCUMULATION, ACTIVATION, EXPRESSION
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses during chronic infection. Hence, studying the role of HBV in immune suppression is very important for the development of alternative therapeutic strategies for HBV infections.