Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.39, sa.3, ss.187-194, 2014 (Scopus)
The purpose of this study was to investigate the relation between slime production and antibiotic resistance of 100 staphylococci isolated from various clinical specimens (wound, blood, tracheal aspirates, sputum, urine, synovial fluid, catheter tip, ear) at Etlik Lokman Hekim and Etlik Training and Research Hospitals, Ankara, Turkey between February-April 2011. Slime production was determined by Congo Red Agar (CRA) method and antibiotic susceptibilities were determined by Kirby-Bauer disk diffusion method according to the Clinical and Laboratory Standards Institute recommendations. Gram staining, catalase testing, coagulase testing and hemolytic properties were used to identify isolates. According to the results 42 isolates were determined as Staphylococcus aureus and 58 isolates were determined as coagulase negative staphylococci (CNS). Slime production was detected in 17 of 58 CNS and 20 of 42 S.aureus. All isolates tested were susceptible to vancomycine, teikoplanin and linezolid. Resistance to oxacillin in slime positive isolates were detected higher than the slime negative strains, the highest resistance was detected in CNS. All of slime positive strains and most of slime negatives were resistant to penicillin and ampicillin. Resistance to ciprofloxacin, ofloxacin, erythromycine, cefazolin, gentamicin, clindamycin, tetracycline ve rifampicin were detected higher in slime positive strains compared to negative strains. As a result, slime positive isolates perform higher resistance to antibiotics.