The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

Ceyhan, GÜRALP; Bergmann, Frank; Kadihasanoglu, Mustafa; Erkan, Mert; Park, Weon; Hinz, Ulf; Mueller, Michael; Giese, Thomas; Buechler, Markus; Giese, Nathalia; Friess, Helmut

doi:10.1136/gut.2006.105528

The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

Atıf İçin Kopyala

Ceyhan G. , Bergmann F., Kadihasanoglu M., Erkan M., Park W., Hinz U., ...Daha Fazla

GUT, cilt.56, ss.534-544, 2007 (SCI İndekslerine Giren Dergi)

Cilt numarası: 56 Konu: 4
Basım Tarihi: 2007
Doi Numarası: 10.1136/gut.2006.105528
Dergi Adı: GUT
Sayfa Sayıları: ss.534-544

Özet

Background and aim: Chronic pancreatitis is characterised by severe abdominal neuropathic pain, perineural inflammatory cell infiltrations and intrapancreatic neural growth. Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFR alpha 3 was investigated in patients with chronic pancreatitis.