The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

Ceyhan G. , Bergmann F., Kadihasanoglu M., Erkan M., Park W., Hinz U., ...Daha Fazla

GUT, cilt.56, sa.4, ss.534-544, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56 Konu: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1136/gut.2006.105528
  • Dergi Adı: GUT
  • Sayfa Sayıları: ss.534-544


Background and aim: Chronic pancreatitis is characterised by severe abdominal neuropathic pain, perineural inflammatory cell infiltrations and intrapancreatic neural growth. Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFR alpha 3 was investigated in patients with chronic pancreatitis.