The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

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Ceyhan G., Bergmann F., Kadihasanoglu M., Erkan M., Park W., Hinz U., ...More

GUT, vol.56, no.4, pp.534-544, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1136/gut.2006.105528
  • Journal Name: GUT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.534-544
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background and aim: Chronic pancreatitis is characterised by severe abdominal neuropathic pain, perineural inflammatory cell infiltrations and intrapancreatic neural growth. Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFR alpha 3 was investigated in patients with chronic pancreatitis.