The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

Ceyhan, GÜRALP; Bergmann, Frank; Kadihasanoglu, Mustafa; Erkan, Mert; Park, Weon; Hinz, Ulf; Mueller, Michael; Giese, Thomas; Buechler, Markus; Giese, Nathalia; Friess, Helmut

doi:10.1136/gut.2006.105528

The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis

Ceyhan G. , Bergmann F., Kadihasanoglu M., Erkan M., Park W., Hinz U., ...More

GUT, vol.56, no.4, pp.534-544, 2007 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 56 Issue: 4
Publication Date: 2007
Doi Number: 10.1136/gut.2006.105528
Title of Journal : GUT
Page Numbers: pp.534-544

Abstract

Background and aim: Chronic pancreatitis is characterised by severe abdominal neuropathic pain, perineural inflammatory cell infiltrations and intrapancreatic neural growth. Artemin was recently shown to eliminate neuropathic pain and reverse neurochemical damage after nerve injury. The role of artemin and its receptor GFR alpha 3 was investigated in patients with chronic pancreatitis.