Functional effects of a tandem duplication polymorphism in the 5'flanking region of the DRD4 gene

D'Souza U., Russ C., Tahir E., Mill J., McGuffin P., Asherson P., ...More

BIOLOGICAL PSYCHIATRY, vol.56, no.9, pp.691-697, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 9
  • Publication Date: 2004
  • Doi Number: 10.1016/j.biopsych.2004.08.008
  • Journal Name: BIOLOGICAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.691-697
  • Keywords: dopamine receptors, DRD4, ADHD, tandem duplication, polymorphism, regulatory, DEFICIT HYPERACTIVITY DISORDER, DOPAMINE-D4 RECEPTOR GENE, III REPEAT POLYMORPHISM, 2 DISTINCT PROMOTERS, D4 RECEPTOR, 7-REPEAT ALLELE, NOVELTY SEEKING, ASSOCIATION ANALYSIS, 5'-FLANKING REGION, PERSONALITY-TRAIT
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

Background: Several polymorphisms have been identified in the 5' flanking region of the human dopamine receptor gene(DRD4), including a tandem duplication polymorphism. This comprises a 120-base-pair repeat sequence that is known to have different allele frequencies in various populations around the world. Furthermore, various studies have revealed evidence of linkage to attention deficit/hyperactivity disorder disorder and association with schizophrenia and methamphetamine abuse. The location of the polymorphism in the 5' regulatory region of the DRD4 gene and the fact that it consists of potential transcription factor binding sites suggest that it might confer differential transcriptional activity of the alleles.