European Congress of Radiology, Vienna, Austria, 3 - 07 March 2021, pp.164-165
Positive MRI findings in breast cancer patients with pathologic complete
response after neoadjuvant chemotherapy
*S. Erdemli*., F. Takin., . H. Erdodu., F. Tokat., K. Behzatolu.,
N. Meydan., L. .zer., A. Arıcan., C. Uras.; .Istanbul/TR, .Aydın/TR
Purpose: To evaluate the MRI findings of breast cancer patients received
neoadjuvant chemotherapy(NAC) with radiologic partial response(RPR) and
pathologic complete response(PCR)
Methods or Background: In this two-center, retrospective study, imaging and
histopathology records of breast cancer patients with RPR and PCR after NAC
were evaluated. MRI interpretation included lesion morphology at baseline,
changes in morphology, size, and contrast uptake kinetics. PCR was defined
as the absence of invasive tumor cells in the resected breast specimen.
Results or Findings: MRI examinations were performed in 108 women before
and after NAC. RPR were found in 72 HER-2-positive (66.7%:39 hormone
receptor (HR) positive, 33 HR negative), 21 (19.4%) HR-positive/HER-2-
negative, and 15 (13.9%) triple-negative (TN) breast cancer patients. Findings
of MRI after NAC were 53 (49%) non-mass enhancement (NME), 39 (36%)
foci, and 16 (%15) masses. Ductal carcinoma in situ (DCIS), lobular carcinoma
in situ, sclerosing adenosis, and fibrosis were the most common lesions found
in specimens. The most common MRI findings were foci in HER-2-positive
disease and NME in HR-positive and TN disease.
Conclusion: While interpreting MRI after NAC in breast cancer patients, the
presence of contrast enhancement in the original tumor region is considered as
RPR. In PCR cases, positive MRI findings can be related to the presence of
DCIS or other benign proliferative conditions in the original tumor region.
Limitations: The retrospective nature and the limited number of patients are
the major limitations of our study.
Ethics Committee Approval: We applied for institutional ethics committee
Funding for this study: No funding was received for this work.