Positive MRI findings in breast cancer patients with pathologic complete response after neoadjuvant chemotherapy


Erdemli S., Taşkın F. , Erdoğdu İ. H. , Tokat F. , Behzatoğlu K. , Meydan N., ...More

European Congress of Radiology, Vienna, Austria, 3 - 07 March 2021, pp.2

  • Publication Type: Conference Paper / Summary Text
  • City: Vienna
  • Country: Austria
  • Page Numbers: pp.2

Abstract

Positive MRI findings in breast cancer patients with pathologic complete response after neoadjuvant chemotherapy

Preferred Presentation Format

Oral Presentation

Topic

Breast

Support programme applications

none

Authors

S. Erdemli1, F. Taşkin1, İ. H. Erdoğdu2, F. Tokat1, K. Behzatoğlu1, N. Meydan2, L. Özer1, A. Arıcan1, C. Uras11Istanbul/TR, 2Aydın/TR

Body

Purpose or Learning Objective

To evaluate the MRI findings of breast cancer patients received neoadjuvant chemotherapy(NAC) with radiologic partial response(RPR) and pathologic complete response(PCR)

Methods or Background

In this two-center, retrospective study, imaging and histopathology records of breast cancer patients with RPR and PCR after NAC were evaluated. MRI interpretation included lesion morphology at baseline, changes in morphology, size, and contrast uptake kinetics. PCR was defined as the absence of invasive tumor cells in the resected breast specimen.

Results or Findings

MRI examinations were performed in 108 women before and after NAC. RPR were found in 72 HER-2-positive (66.7%:39 hormone receptor (HR) positive, 33 HR negative), 21 (19.4%) HR-positive/HER-2-negative, and 15 (13.9%) triple-negative (TN) breast cancer patients. Findings of MRI after NAC were 53 (49%) non-mass enhancement (NME), 39 (36%) foci, and 16 (%15) masses. Ductal carcinoma in situ (DCIS), lobular carcinoma in situ, sclerosing adenosis, and fibrosis were the most common lesions found in specimens. The most common MRI findings were foci in HER-2-positive disease and NME in HR-positive and TN disease.

Conclusion

While interpreting MRI after NAC in breast cancer patients, the presence of contrast enhancement in the original tumor region is considered as RPR. In PCR cases, positive MRI findings can be related to the presence of DCIS or other benign proliferative conditions in the original tumor region.

Limitations

The retrospective nature and the limited number of patients are the major limitations of our study.

Ethics committee approval

We applied for institutional ethics committee approval.

Funding for this study

No funding was received for this work.

Multicategories

Area of Interest

Breast, Oncology

Imaging Technique

MR

Procedure

Surgery

Special Focus

Cancer, Pathology