European Congress of Radiology, Vienna, Austria, 3 - 07 March 2021, pp.2
Positive MRI findings in breast cancer patients with pathologic complete response after neoadjuvant chemotherapy
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AuthorsS. Erdemli1, F. Taşkin1, İ. H. Erdoğdu2, F. Tokat1, K. Behzatoğlu1, N. Meydan2, L. Özer1, A. Arıcan1, C. Uras1; 1Istanbul/TR, 2Aydın/TR
Purpose or Learning ObjectiveTo evaluate the MRI findings of breast cancer patients received neoadjuvant chemotherapy(NAC) with radiologic partial response(RPR) and pathologic complete response(PCR)
Methods or BackgroundIn this two-center, retrospective study, imaging and histopathology records of breast cancer patients with RPR and PCR after NAC were evaluated. MRI interpretation included lesion morphology at baseline, changes in morphology, size, and contrast uptake kinetics. PCR was defined as the absence of invasive tumor cells in the resected breast specimen.
Results or FindingsMRI examinations were performed in 108 women before and after NAC. RPR were found in 72 HER-2-positive (66.7%:39 hormone receptor (HR) positive, 33 HR negative), 21 (19.4%) HR-positive/HER-2-negative, and 15 (13.9%) triple-negative (TN) breast cancer patients. Findings of MRI after NAC were 53 (49%) non-mass enhancement (NME), 39 (36%) foci, and 16 (%15) masses. Ductal carcinoma in situ (DCIS), lobular carcinoma in situ, sclerosing adenosis, and fibrosis were the most common lesions found in specimens. The most common MRI findings were foci in HER-2-positive disease and NME in HR-positive and TN disease.
ConclusionWhile interpreting MRI after NAC in breast cancer patients, the presence of contrast enhancement in the original tumor region is considered as RPR. In PCR cases, positive MRI findings can be related to the presence of DCIS or other benign proliferative conditions in the original tumor region.
LimitationsThe retrospective nature and the limited number of patients are the major limitations of our study.
Ethics committee approvalWe applied for institutional ethics committee approval.
Funding for this studyNo funding was received for this work.
Area of Interest