Positive MRI findings in breast cancer patients with pathologic complete response after neoadjuvant chemotherapy


Erdemli S., Taşkın F. , Erdoğdu İ. H. , Tokat F. , Behzatoğlu K. , Meydan N., ...More

European Congress of Radiology, Vienna, Austria, 3 - 07 March 2021, pp.164-165

  • Publication Type: Conference Paper / Summary Text
  • City: Vienna
  • Country: Austria
  • Page Numbers: pp.164-165

Abstract

RPS 302-10

Positive MRI findings in breast cancer patients with pathologic complete

response after neoadjuvant chemotherapy

*S. Erdemli*., F. Ta􀃺kin., 􀃸. H. Erdo􀃷du., F. Tokat., K. Behzato􀃷lu.,

N. Meydan., L. .zer., A. Arıcan., C. Uras.; .Istanbul/TR, .Aydın/TR

(srvterdemli@gmail.com)

Purpose: To evaluate the MRI findings of breast cancer patients received

neoadjuvant chemotherapy(NAC) with radiologic partial response(RPR) and

pathologic complete response(PCR)

Methods or Background: In this two-center, retrospective study, imaging and

histopathology records of breast cancer patients with RPR and PCR after NAC

were evaluated. MRI interpretation included lesion morphology at baseline,

changes in morphology, size, and contrast uptake kinetics. PCR was defined

as the absence of invasive tumor cells in the resected breast specimen.

Results or Findings: MRI examinations were performed in 108 women before

and after NAC. RPR were found in 72 HER-2-positive (66.7%:39 hormone

receptor (HR) positive, 33 HR negative), 21 (19.4%) HR-positive/HER-2-

negative, and 15 (13.9%) triple-negative (TN) breast cancer patients. Findings

of MRI after NAC were 53 (49%) non-mass enhancement (NME), 39 (36%)

foci, and 16 (%15) masses. Ductal carcinoma in situ (DCIS), lobular carcinoma

in situ, sclerosing adenosis, and fibrosis were the most common lesions found

in specimens. The most common MRI findings were foci in HER-2-positive

disease and NME in HR-positive and TN disease.

Conclusion: While interpreting MRI after NAC in breast cancer patients, the

presence of contrast enhancement in the original tumor region is considered as

RPR. In PCR cases, positive MRI findings can be related to the presence of

DCIS or other benign proliferative conditions in the original tumor region.

Limitations: The retrospective nature and the limited number of patients are

the major limitations of our study.

Ethics Committee Approval: We applied for institutional ethics committee

approval.

Funding for this study: No funding was received for this work.