A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment

YAPALI S., TURAN İ., Ozutemiz O., Tekesin O.

WIENER KLINISCHE WOCHENSCHRIFT, vol.126, no.23-24, pp.789-791, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 126 Issue: 23-24
  • Publication Date: 2014
  • Doi Number: 10.1007/s00508-014-0610-9
  • Journal Name: WIENER KLINISCHE WOCHENSCHRIFT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.789-791
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No

Abstract

D-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the long-term D-penicillamine treatment in a patient with Wilson's disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting.