Recent advances in research on Crimean-Congo hemorrhagic fever

Papa A., Mirazimi A., Koksal I., Estrada-Pena A., Feldmann H.

JOURNAL OF CLINICAL VIROLOGY, cilt.64, ss.137-143, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 64
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jcv.2014.08.029
  • Dergi Adı: JOURNAL OF CLINICAL VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.137-143
  • Anahtar Kelimeler: Crimean-Congo hemorrhagic fever, Ecology, Epidemiology, TICK-BORNE ENCEPHALITIS, NECROSIS-FACTOR-ALPHA, VIRAL LOAD, CIRCLE AMPLIFICATION, HYALOMMA-MARGINATUM, MOLECULAR-DETECTION, VIRUS-INFECTION, CLIMATE-CHANGE, RIBAVIRIN, INTERFERON
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities. (C) 2014 Elsevier B.V. All rights reserved.