Levels of high-sensitivity C-reactive protein, leptin, and resistin in patients with overt hypothyroidism and subclinical hypothyroidism

Guldiken S., Demir M., Arikan E., Azcan S., Tugrul A.

ENDOCRINOLOGIST, vol.18, no.1, pp.30-33, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1097/ten.0b013e3181652c8d
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.30-33
  • Acibadem Mehmet Ali Aydinlar University Affiliated: No


Hypothyroidism is associated with an increased risk for obesity and cardiovascular diseases. Resistin and leptin exert proinflammatory actions by activating a specific receptors which are expressed in human endothelial cells. The aim of the study was to investigate whether the relations between the leptin, resistin, and high-sensitivity C-reactive protein (hs-CRP), which is a marker of low-grade inflammation, in patients with subclinical (SH) and overt hypothyroidism (OH). The levels of leptin, resistin, and hs-CRP were measured in 25 patients with CH, 30 patients with SH, and in 25 healthy subjects, using enzyme-linked immunosorbent assay method. The leptin and resistin levels in patients with OH and SH were similar to those in the control group. The hs-CRP level in OH group was significantly higher than SH and control groups (P < 0.001, P < 0.001). In the OH group, hs-CRP levels were positively correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.728) and negatively correlated with fF4 levels (P = 0.01 r = -0.51). Combining the OH and SH groups, serum hs-CRP levels were significantly correlated with thyroid-stimulating hormone levels (P < 0.001, r = 0.765) and fr4 (P < 0.001, r = -0.716). No significant correlation was found between hs-CRP and leptin or resistin in patients with OH and SH. We suggest that the elevated hs-CRP levels in hypothyroidism may play a role in the increased risk for atherosclerosis in these patients.