Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.10, sa.1, ss.32-35, 1999 (Scopus, TRDizin)
The aim of this study was to evaluate the association between the topographic distribution, morphology and activity of gastritis in addition to the severity of Helicobacter pylori (H. pylori) infection in patients with various peptic disorders. One hundred and ninety patients (100 F, 90 M; mean age 40.14) were examined endoscopically and evaluated for the presence of gastritis (n: 74), gastroduodenitis (n: 47) and/or duodenal ulcer (DU) (n: 69) disease. Two antral and two corporal biopsy specimens were evaluated histopathologically for gastric morphology, activity and H. pylori intensity. Statistical analysis was performed by chi-square and Spearmann correlation coefficient tests. The morphologic type and activity of gastritis were observed to be more severe in the antrum than the corpus in patients with DU disease (p<0.0001). This observation was found to correlate with H. pylori intensity (p<0.05, r: 0.23). Focal atrophic changes were observed in 14.5% and 5.9 % of biopsy specimens obtained from the antral and corpus mucosa, respectively. Diffuse and focal atrophic gastritis was also encountered more frequently in the antral mucosa of patients with gastritis and gastroduodenitis. However, no significant difference was observed in the topographic distribution with respect to gastritic activity in patients with gastroduodenitis. Antral H. pylori intensity was significantly higher in the antral mucosa than the corpus in all groups (p<0.05). In conclusion, the antral mucosa showed a propensity for a higher grade of gastric activity and bacterial intensity in all groups, especially in patients with DU disease. Furthermore, focal atrophic changes appear to accompany chronic gastritis in the corpus mucosa, in addition to the antrum in patients with DU.