Moclobemide in the treatment of hot flashes in postmenopausal women


Tarim E., Bagis T., Kilicdag E., Erkanli S., Aslan E., Kuscu E.

ADVANCES IN THERAPY, vol.19, no.6, pp.258-265, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1007/bf02853171
  • Journal Name: ADVANCES IN THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.258-265
  • Keywords: moclobemide, hot flashes, menopause, SSRIs, BREAST-CANCER, MENOPAUSAL SYMPTOMS, HYDROCHLORIDE, VENLAFAXINE, DISORDERS, ESTROGENS, THERAPY
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

This randomized, prospective, double-blind study evaluated the efficacy and tolerability of moclobemide, a reversible, selective inhibitor of monoamine oxidase-A, in reducing the frequency and severity of hot flashes. Thirty postmenopausal women were enrolled, and 28 were allocated to 5 weeks of treatment with moclobemide 150 mg (group 1, n = 10), moclobemide 300 mg (group 2, n = 11), or placebo (group 3, n = 9). Data on hot flashes were recorded in a daily diary. Mean reductions in the hot flash severity score were 24.4% in the placebo group, 69.8% in group 1, and 35.0% in group 2. This large difference suggests that the beneficial effects were not due to a placebo effect. Moclobemide may be a new nonhormonal option for reducing the incidence, severity, and duration of hot flashes in postmenopausal women who do not wish to take estrogen or have contraindications to its use.