In vivo half life of nanoencapsulated L-asparaginase

Baran E., Ozer N., Hasirci V. N.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, cilt.13, sa.12, ss.1113-1121, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 12
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1023/a:1021125617828
  • Dergi Adı: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1113-1121
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.