In vivo half life of nanoencapsulated L-asparaginase


Baran E., Ozer N., Hasirci V. N.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol.13, no.12, pp.1113-1121, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 12
  • Publication Date: 2002
  • Doi Number: 10.1023/a:1021125617828
  • Title of Journal : JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
  • Page Numbers: pp.1113-1121

Abstract

In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.