Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome
NEUROLOGY, cilt.68, sa.23, ss.1979-1987, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 23
- Basım Tarihi: 2007
- Doi Numarası: 10.1212/01.wnl.0000264417.18604.12
- Dergi Adı: NEUROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1979-1987
- Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır
Özet
Objective: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. Methods: We used [O-15]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. Results: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. Conclusion: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.