Limb Salvage Made Possible Through Neoadjuvant Treatment in Inoperable Infantile Fibrosarcoma

Ayan İ., Özger H., ALPAN B.

Diagnosis and Treatment of Soft Tissue Tumors: Changes, Challenges and Strategies, Springer International Publishing Ag, ss.385-391, 2025 identifier

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/978-3-031-77061-6_42
  • Yayınevi: Springer International Publishing Ag
  • Sayfa Sayıları: ss.385-391
  • Anahtar Kelimeler: Infantile fibrosarcoma, Limb salvage surgery, Neoadjuvant chemotherapy, Pediatric, Prenatal diagnosis, Soft tissue sarcoma, Surgical margins, Wide resection
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Infantile Fibrosarcoma is a malignant fibroblastic tumor that has a locally aggressive behavior and is rarely metastatic. While diagnosis in utero is occasionally possible, most cases are diagnosed within the first year of life, and the most involved sites are the extremities. Tumors can reach huge sizes, eventually involving or even replacing the whole extremity part. The tumor borders are usually infiltrative. Wide local excision is the treatment of choice. Preoperative chemotherapy has an essential role when straightforward excision is not feasible. In this chapter, we present the case of a newborn female patient who had been diagnosed with a sizeable lower leg mass in utero and kept under surveillance with ultrasonography until birth. A trucut biopsy right after birth revealed the diagnosis of infantile fibrosarcoma. While inoperable at birth, limb salvage surgery was only deemed possible following neoadjuvant chemotherapy.