Constitutional growth delay pattern of growth in velo-cardio-facial syndrome: longitudinal follow up and final height of two cases.

DEMİRCİOĞLU S., Ozdemir N., Güran T., Akalin F., Akçay T., Ayabakan C. , ...More

Journal of clinical research in pediatric endocrinology, vol.1, no.1, pp.43-48, 2008 (Refereed Journals of Other Institutions) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1 Issue: 1
  • Publication Date: 2008
  • Title of Journal : Journal of clinical research in pediatric endocrinology
  • Page Numbers: pp.43-48


We report two patients with velo-cardio-facial syndrome (VCFS) who were admitted to our pediatric endocrinology clinic because of short stature and followed longitudinally until attainment of final height. Both patients followed a growth pattern consistent with constitutional delay of puberty with normal and near normal final height. Case 2 also had partial growth hormone (GH) deficiency and severe short stature (height SDS -3.4 SDS), but showed spontaneous catch-up and ended up with a final height of -2 SDS. These cases suggest that short stature in children with VCFS is due to a pattern of growth similar to that observed in constitutional delay of growth and puberty.