Efficacy of Palbociclib and Endocrine Treatment in Heavily Pretreated Hormone Receptor-positive/HER2-negative Advanced Breast Cancer: Retrospective Multicenter Trial


Demir A., Mandel N. M., PAYDAŞ S., Demir G., ER O., Turhal N. S., ...More

Balkan medical journal, vol.37, no.2, pp.104-107, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.4274/balkanmedj.galenos.2020.2019.11.143
  • Journal Name: Balkan medical journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.104-107
  • Keywords: Breast cancer, CDK4/6 inhibitors, palbociclib, COMBINATION, RESISTANCE, LETROZOLE
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Background: The synthesis of CDK4/6 inhibitors with endocrine treatment in two series of treatment has been widely accepted as the standard for patients with estrogen receptor-positive metastatic breast cancer. In spite of this, the activity of CDK4/6 inhibitors in patients with metastatic breast cancer who have progressed despite receiving multiple lines of treatment is not well understood.