Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study

KURGAN Ş., ÖNDER C., Balci N., Akdogan N., ALTINGÖZ S. M., SERDAR M. A., ...Daha Fazla

CLINICAL ORAL INVESTIGATIONS, cilt.26, sa.9, ss.5721-5732, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s00784-022-04528-4
  • Dergi Adı: CLINICAL ORAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.5721-5732
  • Anahtar Kelimeler: Periodontitis, Kynurenine pathway, Tryptophan, INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION, QUINOLINIC ACID, INTERFERON-GAMMA, SERUM TRYPTOPHAN, PATHWAY, INTERLEUKIN-6, DEGRADATION, NEOPTERIN, DISEASE, CANCER
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objectives Kynurenine pathway (KP) is the primary way of degrading tryptophan (TRP) and generates several bioactive metabolites (such as kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxykynurenine (3OHKYN)) to regulate biological processes that include host-microbiome signaling and immune cell response. This study is aimed to determine the relationship between periodontal inflammation and tryptophan-kynurenine metabolism and identify their association with periodontal clinical parameters.