FK506 to prevent lung injury after hindlimb ischemia and reperfusion in a rat model: An electron microscopic study

Akgun, S; Tekeli, A; Isbir, SC; Civelek, A; Ak, K; Sirvanci, S; Arbak, SERAP; Yaylim, I; ARSAN, SİNAN

doi:10.1007/s00595-004-2799-0

FK506 to prevent lung injury after hindlimb ischemia and reperfusion in a rat model: An electron microscopic study

Atıf İçin Kopyala

Akgun S., Tekeli A., Isbir S., Civelek A., Ak K., Sirvanci S., ...Daha Fazla

SURGERY TODAY, cilt.34, sa.8, ss.678-684, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 34 Sayı: 8
Basım Tarihi: 2004
Doi Numarası: 10.1007/s00595-004-2799-0
Dergi Adı: SURGERY TODAY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.678-684
Anahtar Kelimeler: ischemia-reperfusion injury, lung, extremities, NEUTROPHIL INFILTRATION, LIMB ISCHEMIA, FREE-RADICALS, SKIN FLAPS, CYCLOSPORINE, LIVER
Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Purpose. Hindlimb ischemia and reperfusion leads to lung injury in various animal models. We investigated the effectiveness of FK506, an immunosuppressive agent, which also modulates neutrophilic infiltration, in preventing lung injury after hindlimb ischemia and reperfusion in a rat model.