The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats

Balkan J., Parildar F. , Dogru-Abbasoglu S., Aykac-Toker G., Uysal M.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.17, no.9, pp.917-921, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 9
  • Publication Date: 2005
  • Doi Number: 10.1097/00042737-200509000-00006
  • Title of Journal : EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Page Numbers: pp.917-921
  • Keywords: betaine, lipopolysaccharide, liver, oxidative stress, rat, taurine, OXIDATIVE STRESS, CARBON-TETRACHLORIDE, LIPID-PEROXIDATION, ETHANOL, GLUTATHIONE, INJURY, PROTECTION, OSMOLYTE, ACID

Abstract

Background Taurine or betaine have been reported to have antioxidative potential and inhibit Kupffer cell activation. These effects may play an important role in their hepatoprotective effects. Therefore, they may also have protective effects in lipopolysaccharide hepatotoxicity by both inhibiting Kupffer cell activation and behaving as antioxidants.