Zoledronic acid concurrent with either high-or reduced-dose palliative radiotherapy in the management of the breast cancer patients with bone metastases: A phase IV randomized clinical study

Atahan L., Yildiz F., Cengiz M., Kaplan B., Özkan M., Yazici G., ...Daha Fazla

Supportive Care in Cancer, cilt.18, sa.6, ss.691-698, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 6
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00520-009-0663-x
  • Dergi Adı: Supportive Care in Cancer
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.691-698
  • Anahtar Kelimeler: Bone metastasis, Breast cancer, Radiotherapy, Zoledronic acid
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Introduction In this prospective study, the efficacy and safety of radiotherapy combined with zoledronic acid was evaluated. Materials and methods Breast cancer patients with painful bone metastases were randomized to either high- or reduced-dose radiotherapy. All patients received zoledronic acid (4 mg) every 28 days from the beginning of radiotherapy. Analgesic and pain scores in addition to visual analog score (VAS) for treatment satisfaction and whole-body bone scintigraphy were evaluated. Results and conclusion No significant differences could be found in analgesic or pain scores and bone scintigraphy results between the groups. Our results suggest that reduced-dose radiotherapy produces similar response rates and response durations when used concomitantly with zoledronic acid. © 2009 Springer-Verlag.