Early Degeneration of Extracellular Matrix Used for Aortic Reconstruction During the Norwood Operation.

Erek E. , Aydin S. , Suzan D., Yildiz O., Demir I. H. , Odemis E.

The Annals of thoracic surgery, cilt.101, sa.2, ss.758-60, 2016 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Konu: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.athoracsur.2015.04.051
  • Dergi Adı: The Annals of thoracic surgery
  • Sayfa Sayıları: ss.758-60


The use of prosthetic patch material is often required during the surgical reconstruction of complex congenital cardiac malformations. Decellularized porcine small intestinal submucosa, a type of extracellular matrix, was recently introduced as a patch for cardiac and vascular tissue repair. Extracellular matrix was used for aortic reconstruction during the Norwood procedure in 8 consecutive neonates with hypoplastic left heart syndrome. Rapid degeneration or aneurysm formation developed in 3 of these patients who came to secondstage surgery. Extracellular matrix should be used cautiously for aortic reconstruction in infants until additional reports from other centers provide confirmation of its safety. (C) 2016 by The Society of Thoracic Surgeons