Early Degeneration of Extracellular Matrix Used for Aortic Reconstruction During the Norwood Operation.

Erek E., Aydin S., Suzan D., Yildiz O., Demir I. H. , Odemis E.

The Annals of thoracic surgery, vol.101, no.2, pp.758-60, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 101 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1016/j.athoracsur.2015.04.051
  • Journal Name: The Annals of thoracic surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.758-60
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes


The use of prosthetic patch material is often required during the surgical reconstruction of complex congenital cardiac malformations. Decellularized porcine small intestinal submucosa, a type of extracellular matrix, was recently introduced as a patch for cardiac and vascular tissue repair. Extracellular matrix was used for aortic reconstruction during the Norwood procedure in 8 consecutive neonates with hypoplastic left heart syndrome. Rapid degeneration or aneurysm formation developed in 3 of these patients who came to secondstage surgery. Extracellular matrix should be used cautiously for aortic reconstruction in infants until additional reports from other centers provide confirmation of its safety. (C) 2016 by The Society of Thoracic Surgeons