alpha-Lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats


Kolgazi M. , Jahovic N., Yueksel M., Ercan F., Alican I.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.22, no.11, pp.1859-1865, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1440-1746.2006.04504.x
  • Title of Journal : JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Page Numbers: pp.1859-1865

Abstract

Background and Aim: alpha-Lipoic acid (ALA) has been shown to combat oxidative stress by quenching a variety of reactive oxygen species. It is involved in the regeneration of exogenous and endogenous antioxidants, chelation of metal ions, and repair of oxidized proteins. This study aimed to evaluate the potential beneficial effect of ALA on trinitrobenzenesulfonic acid (TNBS)-induced gut ileitis and colitis in rats.