Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis

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Erson-Omay E. Z., Caglayan A. O., Schultz N., Weinhold N., Omay S. B., ÖZDUMAN K., ...Daha Fazla

NEURO-ONCOLOGY, cilt.17, sa.10, ss.1356-1364, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1093/neuonc/nov027
  • Dergi Adı: NEURO-ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1356-1364
  • Anahtar Kelimeler: better prognosis, glioblastoma, polymerase epsilon, germline MSH6 mutation, ultramutated tumor, DNA-POLYMERASE EPSILON, GENOMIC CHARACTERIZATION, GLIOBLASTOMA-MULTIFORME, ENDOMETRIOID CARCINOMA, GERMLINE MUTATIONS, MALIGNANT GLIOMAS, CANCER GENOMICS, MSH6 MUTATIONS, GENES, LANDSCAPE
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Background. Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into disease pathophysiology by correlating genomic landscape with clinical behavior, thereby identifying distinct HGG molecular subgroups associated with improved prognosis, we performed a comprehensive genomic analysis.