NEURO-ONCOLOGY, vol.17, no.10, pp.1356-1364, 2015 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
better prognosis, glioblastoma, polymerase epsilon, germline MSH6 mutation, ultramutated tumor, DNA-POLYMERASE EPSILON, GENOMIC CHARACTERIZATION, GLIOBLASTOMA-MULTIFORME, ENDOMETRIOID CARCINOMA, GERMLINE MUTATIONS, MALIGNANT GLIOMAS, CANCER GENOMICS, MSH6 MUTATIONS, GENES, LANDSCAPE
Acibadem Mehmet Ali Aydinlar University Affiliated:
Background. Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite recent advances, the overall survival of HGGs and their response to treatment remain poor. In order to gain further insight into disease pathophysiology by correlating genomic landscape with clinical behavior, thereby identifying distinct HGG molecular subgroups associated with improved prognosis, we performed a comprehensive genomic analysis.