Bipolar disorder relates to changes in weight and appetite. The ghrelin and leptin are hormones, regulating food intake and energy balance. Thus, we planned to evaluate lipid profiles, leptin and ghrelin levels in the patients with Bipolar disorder in full remission (BD-R) and depressive episode (BD-DE), and in the healthy controls. The study included 49 patients (27 females and 22 males) with bipolar disorder (BD). The patients were enrolled into two subgroups; BD-R (n=30) and BD-DE (n=19) according to DSM-TV, and 24 healthy participants. The morning lipid profiles, leptin and ghrelin levels were measured. The patients were evaluated according to the body mass index (BMI), Young Mania Rating and Hamilton Depression Rating Scales. Although BMI, mean serum leptin levels and lipid profiles have not differed among the groups, increased mean serum ghrelin level was detected in both patients groups compared with controls. Our results suggest that ghrelin may be associated with the symptoms of BD, such as food intake and sleep-wake regulation, but not weight gain although the groups have been matched for sex, age and BMI.