Prognostic value of mesothelin expression in patients with triple negative and HER2-positive breast cancers


Bayoglu I. V. , Kucukzeybek B. B. , Kucukzeybek Y., Varol U., Yildiz İ. , Alacacioglu A., et al.

BIOMEDICINE & PHARMACOTHERAPY, cilt.70, ss.190-195, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 70
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.biopha.2015.01.019
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Sayfa Sayısı: ss.190-195

Özet

Purpose: Mesothelin is a cell surface glycoprotein that is overexpressed in various malignancies. Recent studies have revealed that mesothelin plays an oncogenic role in tumor growth and drug resistance through the Wnt/NF-kappa B/PI3K/Akt signaling pathways. Herein, the expression of mesothelin in HER2-positive and triple-negative breast cancer (TNBC) has been correlated with prognosis.