Role of zafirlukast on skin prick test

Cuhadaroglu Ç., Erelel M., Kiyan E., Ece T., Erkan F.

Allergologia et Immunopathologia, cilt.29, sa.2, ss.66-68, 2001 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0301-0546(01)79020-9
  • Dergi Adı: Allergologia et Immunopathologia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.66-68
  • Anahtar Kelimeler: Allergy test, Anti-leukotrien, Cutaneous reaction, Skin prick test, Zafirlukast
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Background: Some anti-allergic and anti-asthmatic drugs should be discontinued before skin prick test. But there is no knowledge about zafirlukast effects on skin prick test. We investigate the effects of zafirlukast on cutaneous response to histamine and specific allergens. Material and methods: 9 patients suffering from allergic mild asthma or allergic rhinitis and 8 healthy individuals were recruited to the study. All of them took 20 mg zafirlukast twice daily for at least 5 days. Skin prick test was performed before and after treatment by histamine and specific allergens. There was no significant difference between pre- and post- treatment skin prick tests in spite of zafirlukast treatment. Conclusion: zafirlukast does not affect skin reactions against histamine and specific allergens. Diagnostic skin prick test can be performed under zafirlukast treatment.