Gas6 expression and Tyrosine kinase Axl Sky receptors: Their relation with tumor stage and grade in patients with bladder cancer


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Akgul M., Baykan O., ÇAĞMAN Z., ÖZYÜREK M., Tinay I., Akbal C., ...More

ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA, vol.93, no.2, pp.148-152, 2021 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 93 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.4081/aiua.2021.2.148
  • Journal Name: ARCHIVIO ITALIANO DI UROLOGIA E ANDROLOGIA
  • Page Numbers: pp.148-152
  • Keywords: Bladder cancer, Gas6, Axl, Sky, Tyro3, PROTEIN, ACTIVATION, PROMOTES
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Objectives: It has been shown that the dys-regulation of tyrosine kinase Axl receptor and its ligand growth arrest-specific gene (Gas6) are associated with poor prognosis in various types of tumors but there is not enough study about their importance in bladder cancer (BC). We evaluated the relation of Gas6 gene expression and tyrosine-kinase Axl and Sky (Tyro 3) receptors with tumor stage and grade in patients with BC.