Iloprost pretreatment before unilateral nephrectomy: An experimental study in rats

Aytac E., Seymen P., DİKMEN G., Uzun H., SEYMEN H. O.

ASIAN JOURNAL OF SURGERY, cilt.31, sa.2, ss.69-74, 2008 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/s1015-9584(08)60061-5
  • Dergi Adı: ASIAN JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-74
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: To evaluate the effects of iloprost administration before unilateral nephrectomy on postoperative interleukin-6 (IL-6), nitric oxide (NO), and oxidant/antioxidant status. METHODS: Malondialdehyde, glutathione, catalase and Cu-Zn superoxide dismutase were measured in the blood and remnant kidney of Adult male Wistar albino rats to asses oxidant and antioxidant status. The rats were divided into three experimental groups: sham group (S) (n = 12); unilateral nephrectomized group (N) (n = 12); an hour before unilateral nephrectomy iloprost (1 ng/mL/kg, intraperitoneal) administered group (IN) (n = 12). RESULTS: Iloprost administration before unilateral nephrectomy lowered oxidant parameters and IL-6 levels significantly. NO levels were increased in both N and IN groups. CONCLUSION: Iloprost pretreatment before unilateral nephrectomy can reduce oxidative stress and IL-6, which increases due to anaesthesia and surgery and causes organ damage during surgery and in the short-term postoperative period.