Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties

Tuncel S., Trivella A., Atilla D., Bennis K., Savoie H., Albrieux F., ...Daha Fazla

MOLECULAR PHARMACEUTICS, cilt.10, sa.10, ss.3706-3716, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1021/mp400207v
  • Dergi Adı: MOLECULAR PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3706-3716
  • Anahtar Kelimeler: phthalocyanine, chalcone, photodynamic therapy, antivascular, dual effect, OXYGEN QUANTUM YIELDS, SINGLET OXYGEN, TUMOR VASCULATURE, PHOTOSENSITIZER, 1,3-DIPHENYLISOBENZOFURAN, GROWTH
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Hayır

Özet

Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.