Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties


Tuncel S., Trivella A., Atilla D., Bennis K., Savoie H., Albrieux F., ...Daha Fazla

MOLECULAR PHARMACEUTICS, cilt.10, ss.3706-3716, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 10 Konu: 10
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1021/mp400207v
  • Dergi Adı: MOLECULAR PHARMACEUTICS
  • Sayfa Sayıları: ss.3706-3716

Özet

Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.