Assessing the Dual Activity of a Chalcone-Phthalocyanine Conjugate: Design, Synthesis, and Antivascular and Photodynamic Properties


Tuncel S., Trivella A., Atilla D., Bennis K., Savoie H., Albrieux F., ...More

MOLECULAR PHARMACEUTICS, vol.10, no.10, pp.3706-3716, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 10
  • Publication Date: 2013
  • Doi Number: 10.1021/mp400207v
  • Journal Name: MOLECULAR PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.3706-3716
  • Keywords: phthalocyanine, chalcone, photodynamic therapy, antivascular, dual effect, OXYGEN QUANTUM YIELDS, SINGLET OXYGEN, TUMOR VASCULATURE, PHOTOSENSITIZER, 1,3-DIPHENYLISOBENZOFURAN, GROWTH
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Photodynamic therapy (PDT) and vascular-disrupting agents (VDA) each have their advantages in the treatment of solid tumors, but also present drawbacks. In PDT, hypoxia at the center of the tumor limits conversion of molecular oxygen into singlet oxygen, while VDAs are deficient at affecting the rim of the tumor. A phthalocyanine-chalcone conjugate combining the VDA properties of chalcones with the PDT properties of phthalocyanines was designed to address these deficiencies. Its vascular targeting, photophysical, photochemical, photodynamic activities are reported herein.