Anticancer Therapy for Breast Cancer Patients with Skin Metastases Refractory to Conventional Treatments


Varol U., Yildiz İ. , Alacacioglu A., Uslu R.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.15, no.4, pp.1885-1887, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 15 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.4.1885
  • Title of Journal : ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Page Numbers: pp.1885-1887

Abstract

Skin metastases of breast cancer are usually late events in the course of tumor progression and signify a poor prognosis. They may remain as a therapeutic challenge especially after failure of standard treatments. Topical interventions, together with or without radiotherapy, may only palliate the symptoms temporarily. However, there may be alternative treatment modalities for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy. There are various genetic alterations in tumors and therapeutic potential of expression patterns for factors like epidermal growth factor receptor may have important clinical implications in case of disease refractory to the conventional treatments. Here, we clarified the therapeutic options and genetic alterations in skin metastatic breast cancer patients refractory to standard chemotherapeutics.