Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients


Tuter G., SERDAR M. A. , Yalim M., Gurhan I., Balos K.

JOURNAL OF PERIODONTOLOGY, vol.73, no.11, pp.1273-1278, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 11
  • Publication Date: 2002
  • Doi Number: 10.1902/jop.2002.73.11.1273
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.1273-1278
  • Keywords: cyclosporin A/adverse effects, matrix metalloproteinases, matrix metalloproteinase tissue inhibitors, gingival hyperplasia/pathogenesis, RENAL-TRANSPLANT PATIENTS, CREVICULAR FLUID, GENE-EXPRESSION, GROWTH-FACTOR, MESSENGER-RNA, OVERGROWTH, COLLAGENASE, PERIODONTITIS, HYPERPLASIA, PHENOTYPE

Abstract

Background: Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identify and compare matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in gingival fibroblast cultures of tissues derived from renal transplant patients receiving CsA and exhibiting gingival overgrowth and from periodontally healthy control subjects.