Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients


Tuter G., Serdar M. A. , Yalim M., Gurhan I., Balos K.

JOURNAL OF PERIODONTOLOGY, cilt.73, ss.1273-1278, 2002 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 73 Konu: 11
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1902/jop.2002.73.11.1273
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Sayfa Sayısı: ss.1273-1278

Özet

Background: Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identify and compare matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in gingival fibroblast cultures of tissues derived from renal transplant patients receiving CsA and exhibiting gingival overgrowth and from periodontally healthy control subjects.