Critical review and meta-analysis of biological variation estimates for tumor markers

Marques-Garcia F., Boned B., Gonzalez-Lao E., Braga F., Carobene A., COSKUN A., ...Daha Fazla

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.60, sa.4, ss.494-504, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 60 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1515/cclm-2021-0725
  • Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.494-504
  • Anahtar Kelimeler: biological variation, critical review, meta-analysis, tumor marker, REFERENCE CHANGE VALUES, PROSTATE-SPECIFIC ANTIGEN, ANALYTICAL IMPRECISION, LABORATORY MEDICINE, CLINICAL-PRACTICE, EUROPEAN FEDERATION, CRITICAL-APPRAISAL, SERUM, CEA, CANCER
  • Acıbadem Mehmet Ali Aydınlar Üniversitesi Adresli: Evet

Özet

Objectives Biological variation data (BV) can be used for different applications, but this depends on the availability of robust and relevant BV data. In this study, we aimed to summarize and appraise BV studies for tumor markers, to examine the influence of study population characteristics and concentrations on BV estimates and to discuss the applicability of BV data for tumor markers in clinical practice. Methods Studies reporting BV data for tumor markers related to gastrointestinal, prostate, breast, ovarian, haematological, lung, and dermatological cancers were identified by a systematic literature search. Relevant studies were evaluated by the Biological Variation Data Critical Appraisal Checklist (BIVAC) and meta-analyses were performed for BIVAC compliant studies to deliver global estimates of within-subject (CVI) and between-subject (CVG) BV with 95% CI. Results The systematic review identified 49 studies delivering results for 22 tumor markers; four papers received BIVAC grade A, 3 B, 27 C and 15 D. Out of these, 29 CVI and 29 CVG estimates met the criteria to be included in the meta-analysis. Robust data are lacking to conclude on the relationship between BV and different disease states and tumor marker concentrations. Conclusions This review identifies a lack of high-quality BV studies for many tumor markers and a need for delivery of BIVAC compliant studies, including in different, disease states and tumor marker concentrations. As of yet, the state-of-the-art may still be the most appropriate model to establish analytical performance specifications for the majority of tumor markers.