High grade gliomas need serious follow up in post operative period. It might be necessary to re-operate due to tumor prog-ression in this period. In addition, some changes because of radiotherapy and chemotherapy might act like tumor progres-sion. This condition is called pseudoprogression and its mana-gement is different. Therefore pseudoprogression is a new condition that should be known and considered via following up high grade gliomas. Studies for this subject increase in lite-rature. We aimed to explain this new condition with a case that we assumed as pseudoprogression having high degree glioma.