Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus

Babalik A., ULUS İ. H., Bakirci N., Kuyucu T., Arpag H., Dagyildizi L., ...More

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.57, no.11, pp.5740-5742, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 11
  • Publication Date: 2013
  • Doi Number: 10.1128/aac.01345-13
  • Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5740-5742
  • Acibadem Mehmet Ali Aydinlar University Affiliated: Yes

Abstract

Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.